Dr. RADHA DAYANIDHI

Name:  Dr. Radha Dayanidhi
Designation: Assistant Professor
Qualification:  MSc, BEd, KSET, PhD
Year of Joining:  2019
Work Experience: 15 Years

RESEARCH

A multigenerational assessment upon the environmental exposure of phthalate esters (plasticizers) has contributed to a major threat to humankind. Di-n-butyl phthalate (DBP), one of the plasticisers administered to rats for three generations during gestation and lactation are witnessed with cognitive impairments besides altered histoarchitecture of discrete regions of the brain. The neurobehavioral deficit was evidenced by poor learning and memory in rats. In addition, the exposure of DBP has antagonistic effects on thyroid function through changes in neurotransmitter release and their signalling. This was speculated when rats in the developing stage exposed to DBP for three generations had repercussions as poor neurobehavioral outcomes due to the epigenetic mechanism. The demonstration of the teratogenic and neurotoxic potential of DBP in rats was confounded by associated maternal toxicity and/or pup mortality.

PUBLICATIONS
  • 1. Mahaboob Basha P & Radha MJ. Gestational di-n-butyl phthalate exposure induced developmental and teratogenic anomalies in rats: a multigenerational assessment. Environ Sci and Pollut Res. 2017; 24(5):4537-4551. doi: 10.1007/s11356-016-8196-6
  • Radha MJ and Mahaboob Basha P. Di (n)-Butyl phthalate induced neuronal perturbations in rat brain tissues: A Multigenerational Assessment. Journal of Bioscience and Technology. 2017; 8(1):794-800 ISSN: 0976- 0172. https://jbstonline.com/documents/vol8issue1/jbst2016070101.pdf
  • Mahaboob P Basha, MJ Radha. Gestational and lactational exposition to di-n-butyl phthalate increases neurobehavioral perturbations in rats: A three generational comparative study. Toxicol Rep. 2020; 7:480-491. doi: 10.1016/j.toxrep.2020.03.006
  • Radha MJ, Mahaboob Basha P. Hepatotoxic evaluation of Di-n-butyl phthalate in Wistar rats upon subchronic exposure: A multigenerational assessment. Toxicol Rep. 2020; 7:772- 778. doi: 10.1016/j.toxrep.2020.06.008
  • Radha MJ, Jalaja, Lakshmi PN. Effect of radiation and antioxidant diet on efficacy of silk synthesis of silkworm, Bombyx mori. Res J Chem Environ. 2020; 24 (10):161-170. https://worldresearchersassociations.com/Archives/RJCE/Vol(24)2020/October2020.aspx
  • MJ Radha, Geetika Pant. Characteristic features and signalling cascade of novel zoonotic coronavirus. Sumerianz J biotechnol. 2021; 4 (2): 77-84. doi: 10.47752/sjb.42.77.84
  • Radha MJ, Mahaboob Basha P. Genotoxic impact of di-n-butyl phthalate on DNA: A comparative study of three-generations in the neuronal tissue of Wistar rats. Toxicol Ind Health 2022; 38(3):162–175. doi: 10.1177/07482337221079428
  • M.J. Radha. 2023. “Synergistic interaction of radiation and antioxidant diet on the efficacy of silk performance in silkworm, Bombyx mori.” In A closer look at Silkworms edited by Pratheep Thangaraj New York: 1-118 Nova Science Publishers, Inc.
SUBJECT SPECIALIZATION

Neurotoxicology, Behavioral studies, Biochemistry

MAJOR PROJECTS

  1. Aug 9, 2018 –Feb 16, 2019: Guided project

    Project title: Synergetic Effect of Radiation and Antioxidant on Silk performance of Silkworm, Bombyx mori

    Aug 9, 2018 –Feb 16, 2019: Guided project

    Bombyx mori, the most widely used species in silk farming. The usage of the enriched mulberry diet with antioxidants and radiation exposure had a high potential to increase the synthesis of total proteins, glycogen and cholesterol in the silk gland’s distinct regions namely anterior, middle and posterior as well as in hemolymph found highly beneficial to farmers and sericulture industry to enhance the silk production.

  2. Sep 2022 – 2023

    Project title: Phytochemical, antimicrobial and sensory determinants of behavioural influences in Drosophila spp. of peanut skin extract

SEMINARS, WORKSHOPS AND CONFERENECES
  • Two-week workshop on Research Methodology, ‘Statistical techniques and use of Statistical software’ during April-May 2013 held at Dept. of Statistics, Bangalore University, JB campus.
  • National conference on 'Cell Mechanics and Interactions at the Physics Biology Interface-NCCMI 2013' at Bangalore University, Jnana Bharathi Campus, Bangalore, India on 30 th and 31 st August 2013 at Bangalore and presented a poster entitled “Di (N-butyl) phthalate induced region specific vulnerability in rat central nervous system: A multigenerational assessment.
  • International conference on translational pharmacology, 'Translating Research to Therapy' at NIMHANS Convention Centre, Bangalore, India on 16 th and 18 th December 2013 at Bangalore, India and presented paper entitled “Correlates of oxidative stress indices and cognitive impairments in rats exposed to di-n-butyl phthalate: A multigenerational assessment.
  • National symposium on 'Innovations in Science and Technology for Inclusive Development' at Department of Studies in Zoology on 3 rd and 4 th January 2014, at University of Mysore, Mysore presented a paper entitled, “Changes in oxidative stress indices and cognitive impairments in rats exposed to di-n-butyl phthalate: A multigenerational assessment.
  • International symposium on Translational Neuroscience and 13 th Annual Conference of IAN on, 'Translational research: Novel Approaches to treat Neurological and Psychiatric Disorders' from 1 st to 3 rd November 2014, at NIMHANS displayed a poster entitled, “Multigenerational exposure of phthalates induces neurodegenerative changes in rats’ brain regions.
  • Symposium on 'Healthy Lifestyle and Human Welfare' on 18 th November and 19 th November 2014 at Jnanabharathi, BUB displayed a poster entitled, “Uses of phthalates linked to health impairments: Assessment on Di-n-butyl phthalate induced neurodegenerative changes in rat tissues.
  • National Conference on 'Stress and Health: Frontiers of Research in Stress Related Diseases and Management' during 12 th and 13 th February 2015 at Department of Zoology, Maharani’s Science College for Women, Bangalore presented a paper entitled “Correlates of oxidative stress indices and protein metabolic markers in rat neural tissues upon exposure of Di (-n) butyl Phthalate: A multigenerational assessment.
  • National Conference on 'Recent Advances in Animal Sciences' from 13 th to 15 th February 2015 at Department of Applied Zoology, Mangalore University, Mangalore presented a paper entitled, “Chronic Di(-n)butyl phthalate exposure in rats alters novel molecular targets associated with neurotoxicity: A multigenerational assessment. ?
  • National Conference on 'Ecology, Sustainable Development and Wildlife Conservation (NCESW)' , WACC (Wildlife Awareness and Conservation Club), an association of St. Joseph’s College, Department of Environment Science and Department of Zoology, St. Joseph’s College on Ecology, Sustainable Development and Wildlife Conservation held on 15 th and 16 th December 2016 at St. Joseph’s College presented paper entitled, “Gestational and lactational exposition to di-n-butyl phthalate increases neurobehavioral perturbations in rats: A multigenerational assessment.”
  • National Seminar on ‘Development and Ecological Sustainability: Issues in Emerging India’ from 6 th to 7 th December 2018, held at Dept. of Life Sciences, Christ (Deemed to be University), Bengaluru presented a paper “Gestation mediated exposure of Di-N- Butyl Phthalate ensued variations in hormonal milieu of Wistar rats: A three generational comparative study.
  • Attended InSearch one-day Symposium held on 18 th January 2019 at Jawaharlal Nehru Centre for Advanced Scientific research, Jakkur, Bangalore.
  • Attended one-day seminar on “New Methodology of Assessment & Accreditation by NAAC–Issues and Challenges” on 11 th April 2019 organized by internal quality assurance cell, Ramaiah College of Arts, Science and Commerce.
  • Attended 1 st International Conference on ‘Life, Chemical and Health Sciences (ICLCHS)’ from 24 th to 26 th October 2019 organized by the Department of Life Sciences at Ramaiah College of Arts, Science and Commerce, Bengaluru.
  • Participated in ‘One Week Live Webinar Series of International E-Conference in Plant Sciences’ held at Department of Studies in Botany, Davangere University, Shivagangothri, Davangere-577007, and Karnataka, India on 25th - 30th May 2020.
  • Attended the first Hericure-Valyn-Ukzn international webinar conference on, ‘The impact of natural bioactive compounds for the treatment of covid-19: Diagnostic challenges and futuristic perspectives’ from 30 th - 31 st May 2020 and submitted the abstract entitled, ‘A review of the immunomodulatory potential of natural compounds against COVID19 coronavirus.’
  • Attended two-day national e-conference on ‘Multidisciplinary Science Education and Research using E-tool (MSERE-2020)’ on 29 th and 30 th July 2020 and presented a paper entitled, ‘A Comparative three-generational assessment of renal-toxicity evaluation of di-n-butyl phthalate in Wistar rats.’
  • Attended international conference on ‘Recent Advances in Allied Health and Biological Sciences Research’ on 18 th and 19 th November 2022 and presented paper ‘Versatile strategies for multifaceted Nanoparticle synthesis: An Overview.’
  • Attended 10 days online workshop on "Elementary Bioinformatics" organized by School of Biosciences, IMS Ghaziabad, University courses campus from 24 th June to 3 rd July 2020
  • Participated in the ‘Science Leadership Workshop’ organized by the Central University of Punjab, Bathinda, India from June 22 to June 28, 2020
AWARDS AND RECOGNITION

Best paper presentation for the paper entitled “Gestation mediated exposure of Di-N- Butyl Phthalate ensued variations in hormonal milieu of Wistar rats: A three generational comparative study” in the National Seminar on ‘Development and Ecological Sustainability: Issues in Emerging India’ from 6th to 7th December 2018, held at Dept. of Life Sciences, Christ (Deemed to be University), Bengaluru.

CONTACT
  • Email: radha_biotech@msrcasc.edu.in
    Department of Biotechnology & Genetics
    M.S Ramaiah College of Arts, Science and Commerce
    Bangalore - 560054, India